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Impairment of Prosocial Sentiments is Associated With Frontopolar and Septal Damage in Frontotemporal Dementia

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Report/ 2010/ Pests and philosophers have long acknowledged moral sentiments as key motivators of human social behavior. Prosocial sentiments, which include guilt, pity and embarrassment, enable us to care about others and to be concerned about our mistakes. Functional imaging studies have implicated frontopolar, ventromedial frontal and basal forebrain regions in the experience of prosocial sentiments. Patients with lesions of the frontopolar and ventromedial frontal areas were observed to behave inappropriately and less prosocially, which would be attributed to a generalized emotional blunting. Direct experimental evidence for brain regions distinctively associated with moral sentiment impairments is lacking, however. We investigated this issue in patients with the behavioral variant of frontotemporal dementia

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Media Type Downloadable PDF
Product Id REP000377

Impairment of Prosocial Sentiments is Associated With Frontopolar and Septal Damage in Frontotemporal Dementia

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