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  1. TDP-43 And FUS in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

    TDP-43 And FUS in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

    Report 2010/ The presence of abnormal protein aggregates in the cytoplasm of neurons is a key characteristic of most neurodegenerative diseases. In several common disorders the disease-specific pathological protein was identified, providing the logical basis for research into the underlying biological mechanisms, diagnosis, and treatment. This Review highlights the novel molecular classification of ALS and FTLD that emerged from these findings and summarises developments in the clinicopathological and genetic knowledge of disorders involving TDP-43 and FUS. Learn More

    Downloadable PDF

    REP000528

    $5.00
  2. Oxidative Stress In Alzheimer's Disease Hippocampus: A Topographical Study

    Oxidative Stress In Alzheimer's Disease Hippocampus: A Topographical Study

    Report 2010/ Advanced glycation end-productions (AGEs) and their receptor (RAGE) are molecules related to oxidative stress demonstrated in aging and in several pathological disorders including Alzheimer's disease (AD). Aging has been considered the main risk factor for AD. Amyloid deposits (A?-D) and neurofibrillary tangles (NFT) are pathological changes related to AD involving hippocampal regions. Different degrees of AD pathology have been described according to distributions of NFTs in different topographical regions of hippocampus and cerebral cortex. Learn More

    Downloadable PDF

    REP000359

    $5.00
  3. Capillary Caa And Perivascular A?-Deposition: Two Distinct Features Of Alzheimer's Disease Pathology

    Capillary Caa And Perivascular A?-Deposition: Two Distinct Features Of Alzheimer's Disease Pathology

    Report 2010/ Cerebral amyloid angiopathy (CAA) is frequently seen in Alzheimer's disease (AD) cases and represents one of its histiopathological hallmarks. CAA is characterized by amyloid ?-protein (A?) deposits within vessel walls. In addition to arteries and veins capillaries can also be affected. A? deposition into the capillary wall is, thereby, known as capillary CAA (capCAA) and strongly associated with the apolipoprotein E APOE?4 allele as a risk factor. A? deposits along the pericapillary glia limitans are described as pericapillary A? (pericapA?: synonymous with pericapillary CAA in other studies). Here, we studied the relationship between pericapA? and capCAA in 58 human autopsy cases. Learn More

    Downloadable PDF

    REP000358

    $5.00
  4. Systematic Evidence Review Of The Signs And Symptoms Of Dementia And Brief Cognitive Tests Available In Va

    Systematic Evidence Review Of The Signs And Symptoms Of Dementia And Brief Cognitive Tests Available In Va

    Report 2010/ HSR&D's Evidence-based Synthesis Program (ESP) was established to provide timely and accurate syntheses of targeted healthcare topics of particular importance to VA managers and policymakers, as they work to improve the health and healthcare of Veterans. The ESP disseminates these reports throughout VA. HSR&D provides funding for four ESP Centers and each Center has an active VA affiliation. The ESP Centers generate evidence syntheses on important clinical practice topics. Learn More

    Downloadable PDF

    REP000343

    $5.00
  5. Care Giving In Dementia: Contours Of A Curriculum

    Care Giving In Dementia: Contours Of A Curriculum

    Report 2010/ The article starts out by describing the suffering and problems confronting people with dementia and their families, elaborating various factors that determine how they cope with the trauma of the disease. Against this background, the tasks for professional care-givers are then identified. Care-giving in dementia is a specialty that should be based on a high level of expertise and a professional approach - but changes are essential if we want to provide 'good care' and ensure support for the increasing number of people with dementia. Core topics are then set out, forming the building blocks for a curriculum, with contours based on the relational perspective of caring for people with dementia. Learn More

    Downloadable PDF

    REP000342

    $5.00
  6. High Rise Assisted Living CCRC Education Link

    High Rise Assisted Living CCRC Education Link

    DVD 2011 / The continuum of care model (independent living/assisted living/nursing home/dementia) all under a single roof, and providing a guarantee of a last stop, irrespective of any medical outcome. Built in precinct of an educational institution (Stanbord University in San Francisco). Targeted at University Alumni. Extends continuum of care into the continuum of learning. Learn More

    DVD

    DVD000079

    $19.00
  7. Clinics in Geriatric Medicine

    Clinics in Geriatric Medicine

    Healthy brain ageing/ Evidence based methods to preserve brain function and prevent dementia/ Hardcover/ 170 pages/ 2010 (August)/ This issue examines what is a healthy aging brain and covers preventive measures for successful cognitive aging. Topics covered include: A road map to healthy aging brain; Cardiovascular risk factors; Cerebrovascular disease burden and healthy aging brain; Healthy aging brain: Impact of head injury, alcohol and environmental toxins; Healthy aging brain: What has sleep got to do with it?; Endocrine aspects of healthy aging brain; Healthy aging brain: Role of exercise and physically active lifestyle; Healthy aging brain: Role of nutrition and nutritional supplements; Healthy aging brain: Role of cognitive reserve, cognitive stimulation and cognitive exercises; Healthy aging brain: Impact of positive and negative emotions; Dementia risk predictor. Learn More

    Book

    BKS000351

    $64.59
  8. Cognitive Impairment and Dementia in Parkinsons Disease

    Cognitive Impairment and Dementia in Parkinsons Disease

    Hardcover/ 288 pages/ 2010/ Parkinson's disease has long been perceived as a pure motor disorder, partly due to its initial description by James Parkinson, who suggested that "sense and intellect remain intact", and partly due to the fact that patients with PD did not survive long, before effective treatment became available. As the survival time of patients with Parkinson's diseases has substantially increased due to modern treatment, it has become apparent that cognitive deficits and dementia are also frequent features, especially in elderly patients. With the progression of the disease and age, dementia develops in a substantial number of patients and constitutes a major therapeutic challenge. Dementia has thus increasingly been the focus of research and practice in recent years and a large body of knowledge has been accumulated. Despite these developments there has been no single volume dedicated to this topic. This book provides an extensive overview of the current status of knowledge pertaining to cognitive impairment and dementia associated with Parkinson's disease. Learn More

    Book

    BKS000347

    $52.25
  9. The Handbook of Alzheimer's Disease and Other Dementias

    The Handbook of Alzheimer's Disease and Other Dementias

    Hardcover/ 504 pages/ 2011 (April)/ Provides the reader with a comprehensive review of Alzheimer's disease and other Dementias, from both basic and clinical neuroscience perspectives, in a single volume. Contains an update on the current genetic risk factors and pathophysiologic mechanisms related to dementia/ Section IV, "Neuroimaging in Dementia," includes in-depth information on this exciting and fast-paced field. There is no volume that encompasses the specific range of topics presented in this volume. Other volumes on the market are focused more narrowly on either basic sciences or behavioral and clinical sciences. The combination of basic molecular perspectives and cognitive neurosciences is novel. Learn More

    Book

    BKS000323

    $71.25
  10. Palliative and Nursing Home Care

    Palliative and Nursing Home Care

    Policies, Challenges and Quality of Life/ Hardcover/ 2011/ This book examines the policies, challenges, and quality of life issues in palliative care and nursing home care facilities. Some topics discussed in this compilation include: identifying the palliative are needs of home-based dementia patients and their caregivers; the functions of sexuality in older adults living in nursing homes and increasing awareness of staff and family members to this issue; haematology and non-oncological respiratory patients in palliative acre; the changing roles of the licensed practical nurse in nursing home care; obese nursing residents and their special considerations; gynecological cancer and palliative cancer care; and neonatal palliative care. Learn More

    Book

    BKS000314

    $107.50

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