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  1. Top Five Trends Shaping Future of Digital Health

    Top Five Trends Shaping Future of Digital Health

    REPORT / 2019 /

    Digital solutions are becoming necessary part of a new global standard of care for patients/residents... Learn More

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    REP998

    $2.00
  2. Changes in U.S. Family Finances from 2010 to 2013

    Changes in U.S. Family Finances from 2010 to 2013

    REPORT / 2014 / This report studies the a widening gap in income and net worth found in American households. Learn More

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    REP000838

    $2.00
  3. Metabolic Alterations Associated With Impaired Clock Drawing in Lewy Body Dementia

    Metabolic Alterations Associated With Impaired Clock Drawing in Lewy Body Dementia

    Report/ 2010/ This clock drawing test (CDT) is a widely used dementia screening instrument that assesses executive and visuospatial abilities; studies in patients with Alzheimer?s disease (AD) suggest frontoposterior networks to be involved in clock drawing. Clock drawing errors are also often observed in dementia with Lewy bodies (DLB), but this functional neuroanatomical substrate of impaired clock drawing has not been firmly established in this disorder. This study was designed to provide initial evidence for brain metabolic alterations associated with CDT performance in DLB. Learn More

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    REP000733

    $5.00
  4. Impairment of Prosocial Sentiments is Associated With Frontopolar and Septal Damage in Frontotemporal Dementia

    Impairment of Prosocial Sentiments is Associated With Frontopolar and Septal Damage in Frontotemporal Dementia

    Report/ 2010/ Pests and philosophers have long acknowledged moral sentiments as key motivators of human social behavior. Prosocial sentiments, which include guilt, pity and embarrassment, enable us to care about others and to be concerned about our mistakes. Functional imaging studies have implicated frontopolar, ventromedial frontal and basal forebrain regions in the experience of prosocial sentiments. Patients with lesions of the frontopolar and ventromedial frontal areas were observed to behave inappropriately and less prosocially, which would be attributed to a generalized emotional blunting. Direct experimental evidence for brain regions distinctively associated with moral sentiment impairments is lacking, however. We investigated this issue in patients with the behavioral variant of frontotemporal dementia Learn More

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    REP000377

    $5.00
  5. Prevention of Dementia

    Prevention of Dementia

    Report 2011/ Dementia is often the umbrella term under which there are several subcategories. Alzheimer disease (AD) is the most common form of dementia in aging and is a degenerative disorder. At present, AD can only be characterized definitively at the time of autopsy. However, a great deal of research is being conducted to define biomarkers characteristic of the underlying pathological process that can be identified in life. This article addresses the research trying to understand the underlying nature of these disorders with the intention of developing disease modifying treatments. Learn More

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    REP000580

    $5.00
  6. In Vivo Amyloid Imaging In Autopsy-Confirmed Parkinson Disease With Dementia

    In Vivo Amyloid Imaging In Autopsy-Confirmed Parkinson Disease With Dementia

    Report 2010/ This study investigates the specificity of in vivo amyloid imaging with [??C]-Pittsburgh Compound B (PIB) in Parkinson disease dementia (PDD). The study performed detailed neuropathological examination for 3 individuals with PDD who had PIB PET imaging within 15 months of death. The study examines whether the ability to specifically identify fibrillar A? amyloid in the setting of a-synucleinopathy makes [??C]-PIB PET a valuable tool for prospectively evaluating how the presence of A? amyloid influences the clinical course of dementia in patients with Lewy body disorders. Learn More

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    REP000535

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  7. TDP-43 And FUS in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

    TDP-43 And FUS in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

    Report 2010/ The presence of abnormal protein aggregates in the cytoplasm of neurons is a key characteristic of most neurodegenerative diseases. In several common disorders the disease-specific pathological protein was identified, providing the logical basis for research into the underlying biological mechanisms, diagnosis, and treatment. This Review highlights the novel molecular classification of ALS and FTLD that emerged from these findings and summarises developments in the clinicopathological and genetic knowledge of disorders involving TDP-43 and FUS. Learn More

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    REP000528

    $5.00
  8. Oxidative Stress In Alzheimer's Disease Hippocampus: A Topographical Study

    Oxidative Stress In Alzheimer's Disease Hippocampus: A Topographical Study

    Report 2010/ Advanced glycation end-productions (AGEs) and their receptor (RAGE) are molecules related to oxidative stress demonstrated in aging and in several pathological disorders including Alzheimer's disease (AD). Aging has been considered the main risk factor for AD. Amyloid deposits (A?-D) and neurofibrillary tangles (NFT) are pathological changes related to AD involving hippocampal regions. Different degrees of AD pathology have been described according to distributions of NFTs in different topographical regions of hippocampus and cerebral cortex. Learn More

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    REP000359

    $5.00
  9. Capillary Caa And Perivascular A?-Deposition: Two Distinct Features Of Alzheimer's Disease Pathology

    Capillary Caa And Perivascular A?-Deposition: Two Distinct Features Of Alzheimer's Disease Pathology

    Report 2010/ Cerebral amyloid angiopathy (CAA) is frequently seen in Alzheimer's disease (AD) cases and represents one of its histiopathological hallmarks. CAA is characterized by amyloid ?-protein (A?) deposits within vessel walls. In addition to arteries and veins capillaries can also be affected. A? deposition into the capillary wall is, thereby, known as capillary CAA (capCAA) and strongly associated with the apolipoprotein E APOE?4 allele as a risk factor. A? deposits along the pericapillary glia limitans are described as pericapillary A? (pericapA?: synonymous with pericapillary CAA in other studies). Here, we studied the relationship between pericapA? and capCAA in 58 human autopsy cases. Learn More

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    REP000358

    $5.00
  10. Systematic Evidence Review Of The Signs And Symptoms Of Dementia And Brief Cognitive Tests Available In Va

    Systematic Evidence Review Of The Signs And Symptoms Of Dementia And Brief Cognitive Tests Available In Va

    Report 2010/ HSR&D's Evidence-based Synthesis Program (ESP) was established to provide timely and accurate syntheses of targeted healthcare topics of particular importance to VA managers and policymakers, as they work to improve the health and healthcare of Veterans. The ESP disseminates these reports throughout VA. HSR&D provides funding for four ESP Centers and each Center has an active VA affiliation. The ESP Centers generate evidence syntheses on important clinical practice topics. Learn More

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    REP000343

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